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Table 1 Literature review of ring 18 cases in acute myelogenous leukemia

From: Ring chromosome 18 abnormality in acute myelogenous leukemia: the clinical dilemma

Karyotype [Number of cells] Antecedent disease Disease Treatment Followup Reference
45, XY, der(1)t(1;11)(p36;q23), -11, dmin(18)46, XY, r(18), dmin(1) [NA]/46, WY, dmin(1) MDS AML-M4 ARA-C Died Michalova et al[10]
46, XX, r18(p11q21) [NA]/46, XX Hodgkin's disease NA NA NA Lee et al[4]
46, XY, r(18)(p11q23)[9%] NA AML-M4 NA 18+months Testa et al[5]
43-46, XX, -3, -5, -7, +8, r(18), +20, dmin[cp19]/46, XX[1] Multiple myeloma AML VAD
NA Sawyer et al[11]
r(18) and r(20) present. Full karyotype not available NA AML NA NA Gisselsson et al[12]
47, +21, r(?18)[31] NA AML-either M1 or M2 NA NA Fitzgerald et al[13]
39-44, Y, der(X)t(X;9) (p11.2;?q32), del(1)(p13p32), t(1;10)(p21;q26), der(5)t(X;5)(p11.2;q11), -9, der(?16)r(16;
18)(?;?q11?q12), der(17)t(9;17)(?;p11), -18[cp3]
NA tAML NA NA Mrozek et al[14]
44, XX, del(2p), del(5q), - 7, - 9, - 14, der(l7]<i(l7p)?>, -18, r(18), - 21, + 22, + mar.variations [21] NA AML-M4 NA NA GFCH[15]
Ring 18 present but karyotype not available so unclear if this is a sole abnormality NA NA NA NA Schoch et al[16]
45, XX, -7. r(18)[15] NA AML-M6 NA Lost to followup Gibbons et al[17]
  1. NA: not available; VAD: vincristine, adriamycin, dexamethasone; MP: melphalan, prednisone; VMCP: vincristine, melphalan, cyclophosphamide, prednisone; VBAP: vincrisitne, carmustine, doxorubicine, prednisone; CY: cyclophosphamide; TBI-F10: total body irradiation in fractionated doses of 10 Gy