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Table 2 Risk of autoimmune conditions in hairy cell leukemia cases compared to controls

From: Autoimmune conditions and hairy cell leukemia: an exploratory case-control study

Autoimmune condition

Controls with autoimmune condition

HCL cases with autoimmune condition

Association before HCL dx/control selection

Association at HCL dx/control selection

Association after HCL dx/control selection

 

No. (%)

No. (%)

Odds Ratio (95%CI)*

Odds Ratio (95%CI)*

Hazard Ratio (95%CI)*

Addison disease

614 (0.4)

< 5

2.1 (0.3-15.2)

-

1.1 (0.9-1.3)

Alopecia areata

169 (0.1)

0

-

-

-

Ankylosing spondylitis

251 (0.2)

< 5

-

12.2 (1.7-90.7)

-

Chronic rheumatic heart disease

10,405 (6.5)

23 (5.5)

0.8 (0.4-1.7)

1.4 (0.6-3.2)

1.0 (1.0-1.1)

Crohn disease

546 (0.3)

< 5

-

10.2 (2.5-41.7)

-

Discoid lupus erythematosus

273 (0.2)

0

-

-

-

Erythema nodosum

86 (0.1)

< 5

37 (4.9-284)

-

-

Giant cell arteritis

899 (0.6)

< 5

2.2 (0.6-9.1)

-

-

Goodpasture syndrome

13 (0.0)

0

-

-

-

Graves disease

727 (0.5)

0

-

-

-

Hashimoto thyroditis

588 (0.4)

< 5

1.7 (0.2-12.1)

10.3 (2.5-42.3)

-

Systemic lupus erythermatosus

545 (0.3)

< 5

1.8 (0.3-13.0)

7.2 (2.3-22.8)

1.1 (0.9-1.4)

Meniere syndrome

800 (0.5)

< 5

1.0 (0.1-7.2)

-

1.1 (0.9-1.4)

Myasthenia gravis

232 (0.1)

0

-

-

-

Pernicious anemia

5,229 (3.3)

17 (4.1)

1.1 (0.5-2.8)

3.4 (1.6-7.1)

1.0 (0.9-1.1)

Polymyositis

206 (0.1)

0

-

-

-

Polymyalgia rheumatica

2,721 (1.7)

9 (2.6)

1.5 (0.5-3.9)

1.1 (0.2-8.0)

1.1 (1.0-1.2)

Psoriasis

2,655 (1.7)

< 5

0.8 (0.2-2.3)

1.0 (0.1-7.0)

-

Rheumatoid arthritis

6,557 (4.2)

12 (4.1)

1.3 (0.7-2.5)

1.0 (0.2-3.9)

0.9 (0.7-1.1)

Sarcoidosis

167 (0.1)

< 5

9.6 (2.4-39.5)

 

-

Localised scleroderma

345 (0.2)

0

-

-

-

Systemic sclerosis

156 (0.1)

0

-

-

-

Sjögren syndrome

472 (0.3)

5 (1.2)

6.1 (2.0-19.3)

7.9 (1.1-57.5)

1.2 (0.9-1.5)

Ulcerative colitis

951 (0.6)

< 5

0.8 (0.1-5.6)

2.8 (0.4-19.8)

-

  1. Notes:
  2. Abbreviations: HCL hairy cell leukemia, dx diagnosis
  3. The table includes only autoimmune conditions that had a prevalence of greater than 0.1% in controls. Associations that were significant at p < 0.05 are underlined. Observations where the number of exposed cases or controls is between 1 and 4 are listed as " < 5" to preserve subjects' anonymity, in accordance with the SEER-Medicare data use agreement.
  4. Associations that are significant at p < 0.05 are underlined.
  5. * Analyses were adjusted for age (67-69, 70-74, 75-79, 80-84 and 85-99 years), gender, race (white, non-white) and selection year (1987-1996, 1997-1999, 2000-2001, 2002).
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Journal of Hematology & Oncology

ISSN: 1756-8722

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