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Table 3 Clinical studies of panobinostat (LBH589)

From: Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents

Phase Disease (pt. No.) Schedule Recommended dose & response Reference
I Relapsed or refractory AML (15), MDS (1) and ALL(1). Day 1 to 7 of a 21-day cycle 11.5 mg/m2 [108]
I Cutaneous T-cell lymphoma(9) Monday, Wednesday and Friday of each week on a 28-day cycle 20 mg a day,
CR 22.2%, PR 44.4%, SD 11.1%, POD 22.2%
[105]
I Castration-resistant prostate cancer (16) Arm I: 20 mg on 1,3 and 5 for 2 weeks on a 28-day cycle; Arm II: 15 mg on 1,3 and 5 for 2 weeks on a 28-day cycle with docetaxel and prednisone Arm I: POD 100%; arm II: PR 37.5% [112]
II Advanced CTCL(stage IB-IVA)
Group 1 previously treated with bexarotene(25); group 2 bexarotene naïve(15)
Days 1,3, and 5 weekly until disease progression or intolerance Group 1:
PR12%, SD16%, PD12%;other patients and most patients in groups have had less than 2 months of follow-up.
[109]