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Table 3 Pharmacokinetic parameters of everolimus

From: Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors

Parametera

Everolimus 5 mg/day

(n = 12)

Everolimus 10 mg/day

(n = 12)

AUC0-τ, h•ng/mL

316.1 (34.8)

588.6 (41.4)

CL/F, L/h

15.8 (34.8)

16.99 (41.4)

Cmax, ng/mL

28.8 (31.3)

53.8 (56.2)

Tmax, h (range)

2.96 (1.00-4.00)

2.0 (0.92-6.00)

Cmin, ng/mL

8.3 (46.8)

14.5 (47.9)

  1. AUC0-Ï„ = area under the blood concentration-time curve; CL/F = total body apparent clearance of drug from the blood; Cmax = maximum blood concentration; Cmin = pre-dose trough concentration; Tmax = time to reach maximum blood concentration.
  2. aValues shown are means (% coefficient of variation) unless otherwise indicated.
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Journal of Hematology & Oncology

ISSN: 1756-8722

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