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Table 3 Pharmacokinetic parameters of everolimus

From: Two-dose-level confirmatory study of the pharmacokinetics and tolerability of everolimus in Chinese patients with advanced solid tumors

Parametera Everolimus 5 mg/day
(n = 12)
Everolimus 10 mg/day
(n = 12)
AUC0-τ, h•ng/mL 316.1 (34.8) 588.6 (41.4)
CL/F, L/h 15.8 (34.8) 16.99 (41.4)
Cmax, ng/mL 28.8 (31.3) 53.8 (56.2)
Tmax, h (range) 2.96 (1.00-4.00) 2.0 (0.92-6.00)
Cmin, ng/mL 8.3 (46.8) 14.5 (47.9)
  1. AUC0-τ = area under the blood concentration-time curve; CL/F = total body apparent clearance of drug from the blood; Cmax = maximum blood concentration; Cmin = pre-dose trough concentration; Tmax = time to reach maximum blood concentration.
  2. aValues shown are means (% coefficient of variation) unless otherwise indicated.