Figure 1
From: Suppressing miRNA-15a/-16 expression by interleukin-6 enhances drug-resistance in myeloma cells
Bone marrow stromal cells derived from myeloma patients (MM-BMSCs) suppress apoptosis and miRNA-15a/-16 expression in MM cells. (A) MM-BMSCs inhibited apoptosis of MM cells induced by cytotoxic agent. (B) Stem-loop RT-PCR assay showed that miRNA-15a/-16 expression in MM cells was significantly increased by melphalan and bortezomib treatment. When MM cells were co-cultured with MM-BMSCs, miRNA-15a/-16 expression in MM cells was suppressed. (C & D) IL-6 decreased miRNA-15a/-16 expression in U266 and NCI-H929 cells in a time- and dose- dependent pattern.