Figure 3
From: Impact of bile acids on the growth of human cholangiocarcinoma via FXR
Effect of bile acids and GW4064 (FXR agonist) on tumor growth in vivo. A, effect of bile acids and GW4064 on tumor growth in vivo. The mean volumes of tumor in CDCA and GW 4064 were much less than those of CON group, GDCA group and GDCA+GW 4064 group due to the enhancement of FXR expression. The inhibitory effect in CDCA plus GW 4064 group was even more pronounced. (* p < 0.05). Left panel: tumors at the end of the experiment; right panel: quantitative measures of the tumor volumes. B, Immunohistochemical staining for FXR expression in mice xenograft tissues. Right panel: quantitations of FXR expression in different groups; left panel: representative immunostaining of FXR expression in the tumor tissues. Black arrows point to positive cells.