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Figure 2 | Journal of Hematology & Oncology

Figure 2

From: MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status

Figure 2

MiR-155 expression in CN-AML and in human hematopoietic cells. (A) Relative expression of miR-155 was obtained normalizing with respect to RNU6B. (B) Relative expression of miR-155 was obtained normalizing with respect to RNU54. (C) Mean threshold cycles (Ct) of miR-155 were obtained by qRT-PCR in CN-AML. The ordinate scale is represented with the values in reverse order. The error bar indicates the ± SE. (D and E) Relative expression of miR-155 was obtained by the geometric mean of RNU6B and RNU54 normalization values. (D) CN-AML are subdivided in 2 groups: FLT3wt and FLT3+, each group contains half samples with NPM1wt and half with NPM1+. A significant up-regulation of miR-155 was seen in FLT3+ (ITD-positive) leukemia samples. (E) CN-AML are subdivided in 2 groups: NPM1wt and NPM1+, each group contains half samples with FLT3wt and half with FLT3+. No difference in the expression of miR-155 was observed.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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