Figure 1
From: SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia
FISH and molecular characterization of the t(12;18)(p13.2;q12.3) rearrangement. (A) FISH analysis showing chromosome 12 and 18 breakpoints identification in the follow-up sample (on the left). A schematic representation of genes and BAC clones used in molecular cytogenetic experiments is shown (on the right). (B) RT-PCR experiments showing 5'ETV6/3'BCO51727 produced by the fusion of ETV6 exon 1 with BC051727 exon 3 (underlined). A truncated fusion protein was generated.