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Figure 5 | Journal of Hematology & Oncology

Figure 5

From: HDM2 antagonist MI-219 (spiro-oxindole), but not Nutlin-3 (cis-imidazoline), regulates p53 through enhanced HDM2 autoubiquitination and degradation in human malignant B-cell lymphomas

Figure 5

Upregulation of p53 and p53-target proteins upon HDM2 inhibition. Cells were exposed to increasing concentrations of HDM2 SMIs for 24 h. Whole cell lysates were subjected to SDS-PAGE and probed for specific proteins. Western blots show changes in p53 and its target proteins after 24 h for the 4 cell lines studied. A) The two wt-p53 cell lines, WSU-FSCCL (A1) and KM-H2 (A2) are presented in the top panel. B) The two mt-p53 cell lines, WSU-DLCL2 (B1) and RL (B2) are presented in the lower panel. Representative blots are shown.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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