Figure 9

Activation of HDM2 autoubiquitination and degradation in wt-p53 cell lines exposed to MI-219. Western blots show that patterns of autoubiquitination and degradation differ between the wt-p53 cell lines. A) Data obtained from KM-H2 cells and B) WSU-FSCCL cells exposed to HDM2 SMIs for up to 48 h.