Cell line | Time (h) | Conc. (μM) | Nutlin-3 | MI-219 | ANOVA pa | Post-hoc pb |
---|---|---|---|---|---|---|
WSU-FSCCL | 12 h | 0 | 5.3 ± 0.7 | 5.3 ± 0.7 | p = <0.001 | -- |
2.5 | 7.0 ± 2.5 | 13.7 ± 1.3 | p = <0.001 | |||
5.0 | 8.8 ± 2.0 | 23.8 ± 2.8 | p = <0.001 | |||
10.0 | 10.6 ± 1.7 | 36.1 ± 2.3 | p = <0.001 | |||
24 h | 0 | 6.2 ± 0.7 | 6.0 ± 0.7 | p = <0.0001 | -- | |
2.5 | 9.6 ± 1.6 | 27.6 ± 8.2 | NS | |||
5.0 | 12.3 ± 2.4 | 43.0 ± 18.6 | p = <0.01 | |||
10.0 | 17.3 ± 4.9 | 69.7 ± 6.6 | p = <0.001 | |||
48 h | 0 | 6.1 ± 1.2 | 6.1 ± 1.2 | p = <0.0001 | -- | |
2.5 | 10.1 ± 0.7 | 19.5 ± 1.0 | NS | |||
5.0 | 12.6 ± 1.9 | 35.6 ± 7.6 | p = <0.001 | |||
10.0 | 16.5 ± 2.6 | 74.5 ± 4.9 | p = <0.001 | |||
KM-H2 | 12 h | 0 | 7.9 ± 1.2 | 7.9 ± 1.2 | p = 0.026 | -- |
2.5 | 11.2 ± 1.6 | 12.5 ± 1.3 | NS | |||
5.0 | 11.8 ± 1.5 | 13.5 ± 0.6 | NS | |||
10.0 | 13.6 ± 2.4 | 14.8 ± 2.9 | NS | |||
24 h | 0 | 8.9 ± 1.7 | 8.9 ± 1.7 | p = 0.026 | -- | |
2.5 | 11.2 ± 3.0 | 14.2 ± 2.5 | NS | |||
5.0 | 14.5 ± 3.0 | 19.9 ± 3.5 | NS | |||
10.0 | 20.1 ± 3.8 | 27.9 ± 4.8 | p = 0.05 | |||
48 h | 0 | 2.8 ± 2.5 | 12.8 ± 2.5 | NS |  | |
2.5 | 15.9 ± 6.5 | 19.7 ± 9.4 | ||||
5.0 | 18.9 ± 8.9 | 23.1 ± 10 | ||||
10.0 | 21.1 ± 9.7 | 32.4 ± 9.2 |