Figure 2
From: Angiogenesis in metastatic colorectal cancer and the benefits of targeted therapy
Selected crosstalk between VEGF and other signaling pathways. VEGF signaling intersects with a number of other signaling pathways, including Ang/Tie, Notch/Dll4, integrins, and hypoxia to orchestrate tumor angiogenesis [26, 27, 31–35]. Ang = angiopoietin; Dll4 = delta-like ligand 4; HIF = hypoxia-inducible factor; PlGF = placenta growth factor; VEGF = vascular endothelial growth factor; VEGFR = vascular endothelial growth factor receptor. Dashed arrow indicates Ang-2 can serve as a partial Tie-2 agonist under certain conditions.