Figure 1
Changes in the pancreas weight and histology during the progression of pancreatic cancer in KrasG12Dmouse model. (A) Weight of pancreas during the mice pancreatic cancer progression in KrasG12D transgenic mouse model compared to LSL-KrasG12D mice (*** p-value <0.0001). (B1-B4) Light microscopic pictures (100x) of H&E stained pancreatic sections from unfloxed KrasG12D (LSL-KrasG12D) at 10, 25, 40 and 50 weeks of age, respectively. (B5-B8) Light microscopic pictures (100x) of H&E stained pancreatic sections showing PanIN lesions from floxed KrasG12D (KrasG12D;Pdx1-Cre) at 10, 25, 40 and 50 weeks of age, respectively. (C, D, E) Metastatic lesions from liver, small intestines and lung stained with H&E (100x).