Schematic diagram of metastases and cumulative survival of tumor-bearing nude mice in animal experiments. Occurrence of lung (A), intrahepatic (B), and abdomen metastases (C) significantly increased after PR. Tan IIA decreased the numbers of various metastatic lesions. (D) Survival curves showed that the life-span of test mice was significantly shortened by PR and was markedly prolonged by Tan IIA. Red: HCCLM3. Green: HepG2.