Table 1 Patients characteristics
Characteristic | Number (%) | Mean IC50(nM) | P value |
|---|---|---|---|
Sex | Â | Â | 0.204* |
 Male | 29 (62) | 175.0 ± 127.0 |  |
 Female | 18 (38) | 138.7 ± 126.1 |  |
FAB classification | Â | Â | 0.404 |
  M0 | 4 (9) | 186.7 ± 83.7 |  |
  M1 | 2 (4) | 152.7 ± 89.9 |  |
  M2 | 14 (30) | 156.4 ± 124.6 |  |
  M3 | 9 (19) | 136.2 ± 165.2 |  |
  M4 | 3 (6) | 141.7 ± 116.5 |  |
  M5 | 13 (28) | 153.1 ± 134.5 |  |
  M6 | 2 (4) | 289.9 ± 111.8 |  |
  M7 | 0 (0) |  |  |
Type of AML | Â | Â | Â |
 De novo | 44 (94) | 154.4 ± 115.6 |  |
 Relapsed | 2 (4) | 322.7 ± 326.7 |  |
 MDS | 1 (2) | 134.1 |  |
Cytogenetic class | Â | Â | 0.092 |
 Favorable | 8 (17) | 114.7 ± 121.3 |  |
 Intermediate | 31 (66) | 153.5 ± 121.9 |  |
 Unfavorable | 5 (11) | 168.6 ± 134.5 |  |
 Unknown | 3 (6) | 143.2 ± 65.7 |  |
Flt3 ITD status | Â | Â | 0.092 |
 Wild-type | 23 (49) | 133.1 ± 87.6 |  |
 Mutated | 4 (8) | 89.6 ± 63.4 |  |
 Unknown | 20 (43) | 207.6 ± 157.9 |  |
NPM1 status | Â | Â | 0.135 |
 Wild-type | 23 (49) | 124.7 ± 81.7 |  |
 Mutated | 4 (8) | 137.8 ±115.0 |  |
 Unknown | 20 (43) | 207.6 ± 158.0 |  |