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Table 3 Correlation of DWI and MRP parameters with PFS in HCC and tumor thrombus

From: Magnetic resonance imaging biomarkers in hepatocellular carcinoma: association with response and circulating biomarkers after sunitinib therapy

   Baseline   Percent changes (%)  
Parameters PFS>6 months PFS6 ≤ months P value PFS>6 months PFS6 ≤ months P value
(Median, Range) (Median, Range) (Median, Range) (Median, Range)
RECIST       
HCC (cm) 10.00, 5.20 ~ 14.00 10.00, 2.30 ~ 17.00 0.682 3.57, –36.54 ~ 35.00 7.60, –43.48 ~ 58.23 0.875
Tumor thrombus(mm) 23.87, 22.14 ~ 28.50 30.79, 24.65 ~ 38.34 0.114 −15.23, –25.62 ~ 10.26 9.72, –28.52 ~ 42.92 0.019
mRECIST       
HCC (cm) 10.70, 2.15 ~ 19.56 9.66, 2.24 ~ 15.86 0.207 −0.88, –11.16 ~ 11.00 1.89, –19.84 ~ 15.86 0.517
DWI       
HCC ADC (×10 -3 mm 2 /s) 0.83, 0.65 ~ 1.01 0.90, 0.69 ~ 1.09 0.570 19.48, –12.84 ~ 40.00 22.22, –8.99 ~ 51.72 0.825
Tumor thrombus ADC (×10 -3 mm 2 /s) 0.74, 0.60 ~ 1.03 0.93, 0.79 ~ 1.14 0.085 10.38, –13.28 ~ 39.94 21.11, –62.33 ~ 114.23 0.315
MRP       
HCC Ktrans (min −1 ) 2.80, 1.00 ~ 4.81 1.70, 0.90 ~ 4.1 0.043 −52.27, –83.37 ~ −7.00 −41.25, –75.61 ~ -6.00 0.467
  Kep (min −1 ) 3.01, 1.00 ~ 41.75 2.79, 1.27 ~ 4.36 0.100 −49.58, – 96.32 ~ 28.04 −46.33, –77.05 ~ -1.67 0.914
  EVF 0.93, 0.57 ~ 1.00 0.88, 0.34 ~ 1.00 0.590 −8.77, –47.50 ~ 20.55 –2.38, –30.12 ~ 61.76 0.022
Tumor thrombus Ktrans (min −1 ) 1.65, 0.93 ~ 2.33 1.98, 1.05 ~ 2.99 0.374 −58.48, –72.65 ~ −47.35 −23.11, –63.23 ~ 24.14 0.005
  Kep (min −1 ) 2.43, 1.32 ~ 4.03 1.95, 1.05 ~ 2.76 0.220 −42.53, –67.42 ~ −23.64 −34.58, –80.01 ~ 18.98 0.135
  EVF 0.78, 0.70 ~ 0.92 0.88, 0.82 ~ 0.98 0.120 −11.30, –31.95 ~ 0.56 −22.43, –38.12 ~ −19.75 0.331
  1. Abbreviations: Ktrans Transfer constant; Kep Rate constant; EVF Extracellular volume fraction; ADC Apparent diffusion coefficient.