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Table 3 Frequencies of sera reactivity against protein spots in analyzed groups

From: Autoantibodies to Ezrin are an early sign of pancreatic cancer in humans and in genetically engineered mouse models

Spot no.a

Protein

PDAC

non-PDAC

CP

AD

HS

  

(N = 120)

(N = 50)

(N = 46)

(N = 12)

(N = 40)

1-4

VCL

31%

0%

9%

0%

5%

   

P < 0.0001

P = 0.0024

P = 0.0193

P = 0.0005

5

PDC6I

21%

0 (0%)

7%

0%

3%

   

P < 0.0001

P = 0.0361

P = 0.1221

P = 0.0033

6-9

EZR

56%

12%

2%

17%

10%

   

P < 0.0001

P < 0.0001

P = 0.0135

P < 0.0001

10

hnRNPL

35%

4%

12%

0%

5%

   

P < 0.0001

P = 0.0006

P = 0.0039

P < 0.0001

11

ANXA1

19%

0%

2%

0%

0%

   

P = 0.0003

P = 0.0053

P = 0.2198

P = 0.0012

12

ANXA2

53%

8%

28%

0%

10%

   

P < 0.0001

P = 0.0052

P = 0.0003

P < 0.0001

  1. aReactive protein spots numbered as shown in Additional file 1: Figure S2. Frequencies are expressed as percentage of positive sera; Fisher’s test was performed between PDAC and each control group, P- values < 0.05 were considered statistically significant.