Table 2 A comparison of the histologic and conventional cytogenetic analyses
Cytogenetic findings | No. of patients | No. of BMIhisto+cases | Percentage of abnormal metaphases | BM lymphoma cell percentage†| ||
|---|---|---|---|---|---|---|
BMIhisto+ | BMIhisto- | P value* | ||||
Normal karyotype | 1393 (87.9) | 135/1393 (9.7) | NA | NA | NA | 1 (0–98) |
Abnormal karyotype | 192 (12.1) | 124/192 (64.6) | 49 (8–100) | 25 (5–100) | < 0.001 | 18 (0–95) |
  Single abnormality | 54 (3.4) | 7/54 (13.0) | 35 (8–100) | 25 (9–100) | 0.697 | 5 (0–86) |
   Single numerical abnormality | 42 (2.6) | 4/42 (9.5) | 60 (27–100) | 21 (10–100) | 0.038 | 3 (0–86) |
    Loss of Y | 33 (2.1) | 3/33 (9.1) | 70 (50–100) | 20 (10–100) | 0.021 | 6 (0–86) |
    Loss of another single chromosome | 7 (0.4) | 1/7 (14.3) | 27 | 22 (15–70) | 0.617 | 0‡ |
    Polyploidy | 2 (0.1) | 0/2 (0) | NA | 27 (22–31) | NA | NA |
   Single structural abnormality | 12 (0.8) | 3/12 (25.0) | 15 (8–35) | 67 (9–100) | 0.090 | 5 (0–29) |
  Multiple abnormalities | 138 (8.8) | 117/138 (84.8) | 50 (8–100) | 25 (5–100) | 0.009 | 19 (0–95) |
   2 abnormalities | 10 (0.7) | 6/10 (60.0) | 67 (10–100) | 23 (15–58) | 0.394 | 41 (12–73) |
    1 structural and 1 numerical abnormality | 6 (0.4) | 4/6 (66.7) | 67 (13–92) | 39 (20–58) | 0.355 | 27 (12–50) |
    2 structural abnormalities | 4 (0.3) | 2/4 (50.0) | 55 (10–100) | 20 (15–25) | 0.999 | 61 (49–73) |
   ≥ 3 abnormalities | 128 (8.1) | 111/128 (86.7) | 48 (8–100) | 30 (5–100) | 0.024 | 18 (0–95) |
   (complex karyotype) |  |  |  |  |  |  |