Figure 3

Changes in spleen volume and symptom scores in COMFORT-I by final titrated ruxolitinib dose. (Adapted from Verstovsek S, et al. Management of cytopenias in patients with myelofibrosis treated with ruxolitinib and effect of dose modifications on efficacy outcomes. Onco Targets Ther [published by Dove Press] [22]). Shown are median percentage changes from baseline to week 24 in spleen volume, total symptom score (TSS), abdominal TSS, and cytokine TSS by final titrated ruxolitinib dose (average dose during weeks 21–24). Abdominal TSS includes scores for abdominal discomfort, pain under the ribs on the left side, and early satiety. Cytokine TSS includes scores for night sweats, pruritus, and muscle/bone pain. BID, twice daily.