Figure 2

Best radiological response (RECIST) associated with MK-2206 combinations. CT scan slices demonstrating a CR in a male patient with SCC of the orbit (A). Waterfall plots of the best responses seen in all evaluable patients in arm 1, carboplatin and paclitaxel (B), arm 2, docetaxel (C), and arm 3, erlotinib (D). In arm 1, 6 patients treated in both schedules of MK-2206 with carboplatin and paclitaxel chemotherapy had PRs: with 4 of these being confirmed: melanoma (n = 1, 21-month duration—8 months while on study and 13 months after study discontinuation), neuroendocrine prostate (n = 1, 6-month duration), cervical (n = 1, 6-month duration), and endometrial (n = 1, 4-month duration); and 2 were unconfirmed: gastric (n = 1, 2-month duration) and SCC of the head and neck (n = 1, 2-month duration). In arm 2, a female patient with NSCLC who had progressed through pemetrexed-platinum and erlotinib achieved a PR with MK-2206 200 mg lasting 6 months. The patient withdrew from the study due to docetaxel-related toxicities, before documentation of progressive disease. No objective responses were observed in arm 3: the best response was SD lasting 7 and 6 months in a male patient with NSCLC and a patient with cervical cancer, respectively. Dashed lines indicate the threshold for PD (≥20% increase) and PR (≥30% decrease) based on the change in the sum of target lesions from baseline by Response Evaluation Criteria in Solid Tumors guidelines. CT = computed tomography; CR = complete response; SCC = squamous cell carcinoma; PR = particle response; NSCLC = non-small cell lung cancer; SD = stable disease; PD = progressive disease; QOD = alternate days; Q3W = every 3 weeks; QW = week.