Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions

Table 1 MiRNAs that regulate EMT and their targets in different cancer types

Cancer type	miRNA	Target	Reference
Breast	miR-24	Net1A	[99]
	miR-29a	TTP	[100]
	miR-106b-25	SMAD7	[101]
	miR-221/222	TRPS1	[102]
	miR-374a	WIF1, PTEN, WNT5A	[103]
	miR-375	MTDH	[104]
	miR-448	SATB1	[105]
	miR-506	Vimentin, SNAI2, CD151	[86]
	miR-661	Nectin-1, StarD10	[106]
GC	miR-7	IGF1R	[20]
	miR-27	APC	[107]
	miR-106b-25	SMAD7	[101]
	miR-197	p120 catenin	[108]
HCC	miR-21	PTEN, hSulf-1	[109]
	miR-194	BMI-1	[110]
	miR-490-3p	ERGIC3	[111]
	miR-491	MMP-9	[112]
	miR-612	AKT2	[113]
HNSCC	miR-138	Vimentin, ZEB2, EZH2	[91]
LAD	Let-7c	Bcl-xl	[114]
Liver	miR-216a/217	PTEN, SMAD7	[115]
Lung	miR-365	HMGA2	[116]
Melanoma	miR-137	CtBP1	[117]
NSCLC	miR-134	FOXM1	[118]
	miR-149	FOXM1	[119]
Ovarian	miR-187	Dab2	[120]
Pancreatic	miR-126	ADAM9	[121]

Abbreviations: Net1A Neuroepithelial cell transforming 1, TTP Tristetraprolin, TRPS1 Trichorh inophalangeal 1, WIF1 Wnt inhibitory factor-1, MTDH Metadherin, SATB1 Special AT-rich sequence-binding protein-1, GC Gastric cancer, IGF1R Insulin-like growth factor-1 receptor, APC Adenomatous polyposis coli, HCC Hepatocellular carcinoma, hSulf-1 Human sulfatase-1, BMI-1, B lymphoma mouse Moloney leukemia virus insertion region 1, ERGIC3 Endoplasmic reticulum-Golgi intermediate compartment protein 3, HNSCC Head and neck squamous cell carcinoma, LAD Lung adenocarcinoma, CtBP1 Carboxyl-terminal binding protein 1, NSCLC Non-small cell lung cancer, FOXM1 Forkhead box M1, Dab2 Disabled homolog-2, ADAM9 Disintegrin and metalloproteinase domain-containing protein 9.

ISSN: 1756-8722