Figure 4

Effect of WEB2086 and/or AG1478 on the cell cycle in CAOV-3 and SKOV-3 cell lines. The cell cycle was assessed as described in the Materials and Methods with propidium iodide and RNase staining of CAOV-3 and SKOV-3 cells; the cells were treated with WEB2086 (0.1 mM), AG1478 (10 μM), and their combination. A and C: Representative dot plots illustrating the data near the mean of the groups in B and D. Columns, means of 3 identical wells of a single representative experiment; bars, upper 95% confidence interval; *, p < 0.05 and **, p < 0.005 for comparisons between cells treated with the combined treatment and cells treated with the single agent.