Table 4 Leukemia-associated genes with polymorphisms in 3′UTR (minor allele frequency in caucasians > 0.05)
Gene symbol | Gene name | No. of SNPs in 3′UTR | Gene symbol | Gene name | No. of SNPs in 3′UTR |
|---|---|---|---|---|---|
ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 4 | KRAS | Kirsten rat sarcoma viral oncogene homolog | 9 |
ABL2 | c-abl oncogene 2, non-receptor tyrosine kinase | 4 | LMO2 | LIM domain only 2 (rhombotin-like 1) | 1 |
ACOXL | acyl-CoA oxidase-like | 2 | LPP | LIM domain containing preferred translocation partner in lipoma | 4 |
ARHGAP26 | Rho GTPase activating protein 26 | 3 | MLF1 | myeloid leukemia factor 1 | 4 |
ARNT | aryl hydrocarbon receptor nuclear translocator | 1 | MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 1 |
ATM | ataxia telangiectasia mutated | 4 | NBN | nibrin | 4 |
BAX | BCL2-associated X protein | 1 | NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 2 |
BCL2 | B-cell CLL/lymphoma 2 | 8 | NF1 | neurofibromin 1 | 3 |
BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 2 | NQO1 | NAD(P)H dehydrogenase, quinone 1 | 1 |
BCL3 | B-cell CLL/lymphoma 3 | 1 | P2RX7 | purinergic receptor P2X, ligand-gated ion channel, 7 | 1 |
BCR | breakpoint cluster region | 8 | PBX1 | pre-B-cell leukemia homeobox 1 | 2 |
BRCA2 | breast cancer 2, early onset | 6 | PML | promyelocytic leukemia | 4 |
C12orf5 | chromosome 12 open reading frame 5 | 11 | RUNX1 | runt-related transcription factor 1 | 1 |
CCND1 | cyclin D1 | 4 | RYR2 | ryanodine receptor 2 (cardiac) | 2 |
CCND2 | cyclin D2 | 4 | SEPT9 | septin 9 | 3 |
CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | 2 | SETBP1 | SET binding protein 1 | 1 |
DEK | DEK oncogene | 1 | SKA1 | spindle and kinetochore associated complex subunit 1 | |
ETV6 | ets variant 6 | 7 | STRN4 | striatin, calmodulin binding protein 4 | 1 |
IKZF1 | IKAROS family zinc finger 1 (Ikaros) | 5 | TAL1 | T-cell acute lymphocytic leukemia 1 | 4 |
IRF1 | interferon regulatory factor 1 | 1 | TCF3 | transcription factor 3 | 2 |
IRF4 | interferon regulatory factor 4 | 12 | TCL1B | T-cell leukemia/lymphoma 1B | 1 |
IRF8 | interferon regulatory factor 8 | 5 | TLX1 | T-cell leukemia homeobox 1 | 5 |
KDSR | 3-ketodihydrosphingosine reductase | 2 | ZBTB16 | zinc finger and BTB domain containing 16 | 1 |
KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 2 | ZNF230 | zinc finger protein 230 | 1 |
KMT2A | lysine (K)-specific methyltransferase 2A | 1 |