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Table 2 Toxicology of BENC-511 in nude mice: biochemical analysis

From: Identification of a promising PI3K inhibitor for the treatment of multiple myeloma through the structural optimization

Treatment ALT, U/L AST, U/L BUN, mmol/L Cr, μmol/L
Control 62 (29.3 to 94.7) 237.7 (214.1 to 261.2) 10.3 (9.0 to 11.5) 10.7 (7.9 to 13.5)
BENC-511 48.2 (35.3 to 61.1) 189 (170.8 to 207.2) 11.3 (8.9 to 13.7) 12.4 (11.2 to 13.6)
P 0.6 0.3 0.3 0.4
  1. Data represent mean ± SD of 6 nude in each group after treatment with BENC-511 at 50 mg/kg body weight or vehicle for 20 days. At the completion of the experiment, mice were sacrificed and their sera were prepared for chemistry analysis. Data represent mean values and 95% confidence intervals. ALT = Alanine transaminase; AST = Aspartate aminotransferase; BUN = Blood urea nitrogen; Cr = Creatinine.