Figure 3
From: Tissue factor in tumor microenvironment: a systematic review
Cancer cells escape from T/NK cell immunity via flTF. flTF expressed on tumor cell surface tiggers local coagulation cascase, leading to thrombin gerneration. Thrombin induce C5 cleavage and C5a gerneration. C5a recruits MDSCs into tumor microenvironment and suppress T cell and NK cell anergy. Micrometastasis of tumor cells generates fibrin shield via flTF-induced coagulation, thereby preventing NK cell-induced cytolysis.