Figure 7

YM155 inhibits Eca109 xenografts in response to radiation. A. Tumor volume was measured at the indicated times after the onset of treatment. Data were Mean ± SD from six mice per group; *, P < 0.01, versus control; §, P < 0.05, YM155 plus IR group versus single treatment. B. Mice body weight of different treatments was measured at the indicated times. C. Immunohistochemistry analysis of survivin and cleaved caspase-3 expression and TUNEL analysis for apoptosis in tumor sections after different treatments. Histograms represented the mean intensity of survivin staining (left), the percent of apoptotic cells (middle), and the percent of positive staining of cleaved caspase-3 (right). **, P < 0.01.