FN1 promotes cells mobility and regulates MMP2/MMP9 activity in MGC803 and BGC823 cells; and is involved in the FENDRR -mediated inhibition of metastasis. (A) and (B) FN1 knockdown inhibits the migration and invasion potential of MGC803 and BGC823 cells. (C) FN1 regulates the enzymatic activity of MMP2/MMP-9 in gastric cancer cells. (D) The expression of FN1 protein in BGC-823 cells was analyzed by Western blotting. (E) MMP2/MMP9 expression in BGC823 cells is analyzed by gelatin zymography. (F) Migration and invasion analyses of BGC823 cells is shown. All experiments were performed in triplicate. Bars: SD; *p < 0.05, **p < 0.01.