Schematic representation of mutations. (a) Mutation status of genes assessed in all patients in the study group. Each column represents an individual case. The bottom rows represent, respectively, the cytogenetic risk group (CG) and mutation group (MG) per corresponding color designation. Assessed genes in which mutations were not detected are not included in this diagram. Mutation detection techniques in the MDACC and TCGA groups were different (see Methods section). (b) Distribution of genomic variants within DNMT3A detected in the study group. PWWP represents a region encoding for a highly conserved proline-tryptophan-tryptophan-proline motif. ZNF represents the ADD (ATRX, DNMT3, and DNMT3L)-type zinc finger domain.