Figure 2

Recurrent TP53 pathway alterations in human osteosarcoma. (A) Activating (red) and inactivating (blue) alterations in the p53 and RB1 pathways identified in our cohort. (B) Samples 8, 9, 10 harbored 12q co-amplification of CDK4 and MDM2. 12q amplification was mutually exclusive with alterations in the TP53 gene. (C) Matrix of genetic alterations observed in our cohort. Nine of 11 patients harbored disrupting alterations in the TP53 pathway genes.