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Figure 4 | Journal of Hematology & Oncology

Figure 4

From: Splicing factor 3b subunit 1 (Sf3b1) haploinsufficient mice display features of low risk Myelodysplastic syndromes with ring sideroblasts

Figure 4

Histology of splenic tissues of Sf3b1+/−compared to Sf3b1+/+mice. Spleens from Sf3B1+/− and Sf3b1+/+ mice were fixed in 4% formaldehyde/PBS and embedded in paraffin. Sections were stained with Haematoxylin–Eosin and showed extramedullary hematopoiesis with all 3 hematopoietic elements, increased megakaryocytes with hyperchromatic nuclei (black arrows), increased hemosiderin deposits (blue arrows) and evidence of fibrosis.

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Journal of Hematology & Oncology

ISSN: 1756-8722

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