Figure 1

Involvement of ceRNA-mediated regulation in human cancers. Schematic representation of a simplified ceRNA network with two transcripts and one miRNA (blue circle), and the different cancers for which ceRNA activity has been experimentally verified (orange circles). Different ceRNA subnetworks are represented by squares, where ceRNAs (in blue) interact among each other by binding and competing for common miRNA molecule pools (in green). Validated ceRNA interactions have been reported for breast cancer [39,72-74], melanoma [35], endometrial cancer [38], glioblastoma [36], liver cancer [27,74,75], gastric cancer [40,60], colorectal cancer [17,34,76], prostate cancer [17,34,39], lung cancer [39,55], and lymphoma [41].