A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40

Chen, Jingtao; Zurawski, Gerard; Zurawski, Sandy; Wang, Zhiqing; Akagawa, Keiko; Oh, Sangkon; Hideki, Ueno; Fay, Joseph; Banchereau, Jacques; Song, Wenru; Palucka, A Karolina

doi:10.1186/s13045-015-0131-7

Journal of Hematology & Oncology

Table 2 15-mer cyclin D1 overlapping library

From: A novel vaccine for mantle cell lymphoma based on targeting cyclin D1 to dendritic cells via CD40

Peptide	Position	Sequence	Peptide	Position	Sequence	Peptide	Position	Sequence
1	1–15	MEHQLLCCEVETIRR	26	101–115	LLGATCMFVASKMKE	51	201–215	SMVAAGSVVAAVQGL
2	5–19	LLCCEVETIRRAYPD	27	105–119	TCMFVASKMKETIPL	52	205–219	AGSVVAAVQGLNLRS
3	9–23	EVETIRRAYPDANLL	28	109–123	VASKMKETIPLTAEK	53	209–223	VAAVQGLNLRSPNNF
4	13–27	IRRAYPDANLLNDRV	29	113–127	MKETIPLTAEKLCIY	54	213–227	QGLNLRSPNNFLSYY
5	17–31	YPDANLLNDRVLRAM	30	117–131	IPLTAEKLCIYTDNS	55	217–231	LRSPNNFLSYYRLTR
6	21–35	NLLNDRVLRAMLKAE	31	121–135	AEKLCIYTDNSIRPE	56	221–235	NNFLSYYRLTRFLSR
7	25–39	DRVLRAMLKAEETCA	32	125–139	CIYTDNSIRPEELLQ	57	225–239	SYYRLTRFLSRVIKC
8	29–43	RAMLKAEETCAPSVS	33	129–143	DNSIRPEELLQMELL	58	229–243	LTRFLSRVIKCDPDC
9	33–47	KAEETCAPSVSYFKC	34	133–147	RPEELLQMELLLVNK	59	233–247	LSRVIKCDPDCLRAC
10	37–51	TCAPSVSYFKCVQKE	35	137–151	LLQMELLLVNKLKWN	60	237–251	IKCDPDCLRACQEQI
11	41–55	SVSYFKCVQKEVLPS	36	141–155	ELLLVNKLKWNLAAM	61	241–255	PDCLRACQEQIEALL
12	45–59	FKCVQKEVLPSMRKI	37	145–159	VNKLKWNLAAMTPHD	62	245–259	RACQEQIEALLESSL
13	49–63	QKEVLPSMRKIVATW	38	149–163	KWNLAAMTPHDFIEH	63	249–263	EQIEALLESSLRQAQ
14	53–67	LPSMRKIVATWMLEV	39	153–167	AAMTPHDFIEHFLSK	64	253–267	ALLESSLRQAQQNMD
15	57–71	RKIVATWMLEVCEEQ	40	157–171	PHDFIEHFLSKMPEA	65	257–271	SSLRQAQQNMDPKAA
16	61–75	ATWMLEVCEEQKCEE	41	161–175	IEHFLSKMPEAEENK	66	261–275	QAQQNMDPKAAEEEE
17	65–79	LEVCEEQKCEEEVFP	42	165–179	LSKMPEAEENKQIIR	67	265–279	NMDPKAAEEEEEEEE
18	69–83	EEQKCEEEVFPLAMN	43	169–183	PEAEENKQIIRKHAQ	68	269–283	KAAEEEEEEEEEVDL
19	73–87	CEEEVFPLAMNYLDR	44	173–187	ENKQIIRKHAQTFVA	69	273–287	EEEEEEEEVDLACTP
20	77–91	VFPLAMNYLDRFLSL	45	177–191	IIRKHAQTFVALCAT	70	277–291	EEEEVDLACTPTDVR
21	84–95	AMNYLDRFLSLEPVK	46	181–195	HAQTFVALCATDVKF	71	281–295	VDLACTPTDVRDVDI
22	85–99	LDRFLSLEPVKKSRL	47	185–199	FVALCATDVKFISNP
23	89–103	LSLEPVKKSRLQLLG	48	189–203	CATDVKFISNPPSMV
24	93–107	PVKKSRLQLLGATCM	49	193–207	VKFISNPPSMVAAGS
25	97–111	SRLQLLGATCMFVAS	50	197–211	SNPPSMVAAGSVVAA

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ISSN: 1756-8722

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