Figure 3
Eltrombopag does not inhibit bortezomib or lenalidomide-induced apoptosis of human myeloma cell lines. (A) KMS-11 or (B) OCI-My5 cells were incubated with varying concentrations of eltrombopag in the presence or absence of 1 μM lenalidomide and 10 nM bortezomib for 24 h and apoptosis determined by measuring activation of caspase-3 and −7 activity. Data are presented as mean ± S.D. of triplicate experiments. *p < 0.02. ELT = Eltrombopag; TPO = thrombopoietin; CTRL = control; Len = lenalidomide; Btz = bortezomib.