| |
PB blast reduction ratio (Log10) ( ± SD)
|
|---|
| |
Day 3
|
Day 5
|
Day 7
|
Day 9
|
|---|
|
CR (n = 67)
|
1.09 ± 0.62
|
2.49 ± 0.92
|
3.41 ± 1.02
|
3.92 ± 1.28
|
|
NCR (n = 29)
|
0.70 ± 0.53
|
1.70 ± 0.70
|
2.49 ± 0.95
|
2.91 ± 1.13
|
|
P value
|
0.005
|
<0.0001
|
<0.0001
|
<0.0001
|
|
MRD (+) n = 23)
|
1.05 ± 0.60
|
2.43 ± 1.05
|
3.19 ± 1.11
|
3.62 ± 1.41
|
|
MRD (−) (n = 29)
|
1.25 ± 0.64
|
2.69 ± 0.78
|
3.19 ± 1.11
|
4.15 ± 1.13
|
|
P value
|
0.266
|
0.334
|
0.162
|
0.157
|
|
Relapse (+) (n = 25)
|
0.85 ± 0.45
|
2.00 ± 0.68
|
2.83 ± 0.78
|
3.15 ± 1.02
|
|
Relapse (−) (n = 54)
|
1.12 ± 0.67
|
2.59 ± 0.93
|
3.57 ± 0.98
|
4.16 ± 1.19
|
|
P value
|
0.066
|
0.005
|
0.001
|
0.0005
|
|
Early relapsea (+) (n = 16)
|
0.80 ± 0.45
|
1.91 ± 0.80
|
2.76 ± 0.81
|
3.14 ± 1.10
|
|
Early relapsea (−) (n = 63)
|
1.10 ± 0.65
|
2.52 ± 0.89
|
3.48 ± 0.97
|
4.02 ± 1.19
|
|
P value
|
0.094
|
0.017
|
0.008
|
0.009
|
-
CR achieved complete remission after one course of induction therapy, NCR not achieved complete remission, MRD minimal residual disease. aEarly relapse: hematologic relapse within 6 months.
