Fig. 5
From: Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments
Hematopoietic functional assays of NSI mice. a Summary of percentages of human CD45+ cells in the PB, BM, and SP of NSI (red plot) and NOD-scid (blue plot) mice 20 weeks after injection with 1 × 104 or 1 × 105 purified human CD34+. Bars represent the mean percentages of human CD45+ cells in the PB, BM, and SP of mice from each group (n = 4 or 5 per group). *P ≤ 0.05 for bar 1 versus bar 2, bar 3 versus bar 4, bar 5 versus bar 6, bar 7 versus bar 8, and bar 11 versus bar 12; **P ≤ 0.01 for bar 9 versus bar 10. b Representative FACS analysis of percentages of multiple hematopoietic lineages in NSI as described in (a). c Representative fluorescence-activated cell sorting (FACS) analysis of percentages of multiple hematopoietic lineages in NSI transplanted with human cord blood CD34+/liver/thymus. d The level of human IgG (left) and OVA-specific IgG (right) in serum of NSI mice transplanted with human cord blood CD34+/liver/thymus. Open bars represent NSI mice that received human cord blood CD34+/liver/thymus (n = 3). Data are represented as the mean ± standard error of the mean. **P ≤ 0.01 for bar 3 versus bar 4 and bar 7 versus bar 8. e Representative FACS analysis of percentages of human CD45+ cells in NSI (right) and Nod-scid (left) transplanted with a single primary B-ALL cell