Fig. 1
From: Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia
Kaplan–Meier analysis of the accumulation of MTX polyglutamates and FPGS activity in relation to overall survival (P logrank) of total ALL patients. Each survival curve is labeled with the OS rates at 10 years and the number of patients included in each subgroup. The cut-off values used were: 1935 pmol/109 cells for total accumulation of MTX polyglutamates, 1000 pmol/109 cells for long-chain MTX polyglutamates and 0.35 pmol MTX-Glu2 formed/h/106 cells for FPGS activity