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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Knockdown of SUMO-activating enzyme subunit 2 (SAE2) suppresses cancer malignancy and enhances chemotherapy sensitivity in small cell lung cancer

Fig. 3

SAE2 is associated with apoptosis in SCLC cell line. a Representative FCM result stained by Annexin V-FITC and PI. Annexin V+/PI and Annexin V+/PI+ cells were designed as early stage and advanced stage of the apoptotic process. b The flow cytometry (FCM) results are presented as the percentage of apoptotic cells. The sum of FITC-positive cells in the top right and bottom right quadrants represents the total percentage of apoptotic cells. c Apoptosis-related protein levels were examined by Western blots using β-actin as a loading control. d Cell cycle analysis was performed by FCM and e the percentage of the cell population at different cell cycle phases was shown. Each data point represents means ± SD of three independent experiments (***P < 0.001)

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