Fig. 4

Progression-free survival (PFS) of symptomatic Waldenström macroglobulinemia (WM) patients according to different initial treatments. a Chemotherapy combined with targeted therapy significantly improved the PFS of patients with WM and only bone marrow involvement (BMWM) but had no effect on patients diagnosed with WM with extramedullary involvement (EMWM) (b). c BMWM patients who received treatment with rituximab had better PFS than those treated without rituximab. d Rituximab did not improve PFS in patients with EMWM. e Nucleoside analogs did not affect the outcome of patients with BMWM but improved the PFS of patients with EMWM (f)