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Table 1 Different clinical manifestations and biological features between Waldenström macroglobulinemia (WM) patients with only bone marrow involvement (BMWM) and WM with extramedullary involvement (EMWM)

From: Waldenström macroglobulinemia with extramedullary involvement at initial diagnosis portends a poorer prognosis

Characteristic BMWM EMWM P a
n (%) n (%)
Age    0.048
  ≥ 65 years 94 (45.6) 36 (34.0)
  < 65 years 112 (54.4) 70 (66.0)
Sex    0.027
 Male 103 (50.0) 67 (63.4)
 Female 103 (50.0) 39 (36.6)
Hb    0.240
  ≤ 11.5 (g/dL) 112 (54.4) 65 (61.3)
  > 11.5 (g/dL) 94 (45.6) 41 (38.7)
PLT    0.525
  ≤ 100 (×109/L) 44 (21.4) 26 (24.5)
  > 100 (×109/L) 162 (78.6) 80 (75.5)
IgM    0.726
  > 70 (g/L) 20 (9.7) 9 (8.5)
  ≤ 70 (g/L) 186 (90.3) 97 (91.5)
β2-MG    <0.001
  > 3 (mg/L) 75 (36.4) 71 (64.3)
  ≤ 3 (mg/L) 131 (63.6) 35 (35.7)
LDH (n = 304)    0.906
  > 618 (IU/L) 24 (12.0) 12 (11.5)
  ≤ 618 (IU/L) 176 (88.0) 92 (88.5)
B symptoms    <0.001
 Present 41 (19.9) 44 (41.5)
 Absent 165 (80.1) 62 (58.5)
ALB (n = 307)    0.036
  < 3.5 g/dL 23 (11.3) 21 (20.2)
  ≥ 3.5 g/dL 180 (88.7) 83 (79.8)
IPSSWM stage    0.064
 I 69 (33.5) 35 (33.0)
 II 85 (41.3) 32 (30.2)
 III 52 (25.2) 39 (36.8)
Cytogenetic findings (n = 261)    0.010
 Abnormal 48 (28.2) 40 (44.0)
 Normal 122 (71.8) 51 (56.0)
BM involvement 44.52 ± 1.79 46.50 ± 2.49 0.529
(mean ± SD, %)
  1. Hb hemoglobin, PLT platelet, IgM immunoglobulin M, β2-MG beta-2 macroglobulin level, LDH lactate dehydrogenase, ALB albumin, IPSSWM, International Prognostic Scoring System for WM
  2. a P value by chi-square and Mann–Whitney U tests; statistically significant values appear in italics