Table 1 Different clinical manifestations and biological features between Waldenström macroglobulinemia (WM) patients with only bone marrow involvement (BMWM) and WM with extramedullary involvement (EMWM)
Characteristic | BMWM | EMWM | P a |
|---|---|---|---|
n (%) | n (%) | ||
Age | 0.048 | ||
≥ 65 years | 94 (45.6) | 36 (34.0) | |
< 65 years | 112 (54.4) | 70 (66.0) | |
Sex | 0.027 | ||
Male | 103 (50.0) | 67 (63.4) | |
Female | 103 (50.0) | 39 (36.6) | |
Hb | 0.240 | ||
≤ 11.5 (g/dL) | 112 (54.4) | 65 (61.3) | |
> 11.5 (g/dL) | 94 (45.6) | 41 (38.7) | |
PLT | 0.525 | ||
≤ 100 (×109/L) | 44 (21.4) | 26 (24.5) | |
> 100 (×109/L) | 162 (78.6) | 80 (75.5) | |
IgM | 0.726 | ||
> 70 (g/L) | 20 (9.7) | 9 (8.5) | |
≤ 70 (g/L) | 186 (90.3) | 97 (91.5) | |
β2-MG | <0.001 | ||
> 3 (mg/L) | 75 (36.4) | 71 (64.3) | |
≤ 3 (mg/L) | 131 (63.6) | 35 (35.7) | |
LDH (n = 304) | 0.906 | ||
> 618 (IU/L) | 24 (12.0) | 12 (11.5) | |
≤ 618 (IU/L) | 176 (88.0) | 92 (88.5) | |
B symptoms | <0.001 | ||
Present | 41 (19.9) | 44 (41.5) | |
Absent | 165 (80.1) | 62 (58.5) | |
ALB (n = 307) | 0.036 | ||
< 3.5 g/dL | 23 (11.3) | 21 (20.2) | |
≥ 3.5 g/dL | 180 (88.7) | 83 (79.8) | |
IPSSWM stage | 0.064 | ||
I | 69 (33.5) | 35 (33.0) | |
II | 85 (41.3) | 32 (30.2) | |
III | 52 (25.2) | 39 (36.8) | |
Cytogenetic findings (n = 261) | 0.010 | ||
Abnormal | 48 (28.2) | 40 (44.0) | |
Normal | 122 (71.8) | 51 (56.0) | |
BM involvement | 44.52 ± 1.79 | 46.50 ± 2.49 | 0.529 |
(mean ± SD, %) |