| |
EMWM
|
WM
|
|---|
|
OS
|
PFS
|
OS
|
PFS
|
|---|
|
HR
|
95 % CI
|
P
a
|
HR
|
95 % CI
|
P
a
|
HR
|
95 % CI
|
P
a
|
HR
|
95 % CI
|
P
a
|
|---|
|
Age ≥65 years
|
1.90
|
1.02–3.54
|
0.044
|
1.04
|
0.63–1.73
|
0.876
|
2.09
|
1.32–3.32
|
0.002
|
1.09
|
0.77–1.56
|
0.598
|
|
Sex (male)
|
0.76
|
0.41–1.39
|
0.372
|
0.74
|
0.45–1.22
|
0.239
|
1.06
|
0.59–1.50
|
0.799
|
0.99
|
0.70–1.39
|
0.955
|
|
Race (white)
|
0.72
|
0.29–1.73
|
0.465
|
0.54
|
0.29–1.02
|
0.057
|
0.66
|
0.31–1.40
|
0.281
|
0.59
|
0.35–0.98
|
0.042
|
|
EM-positive
|
-
|
-
|
-
|
-
|
-
|
-
|
4.17
|
2.56–6.79
|
<0.001
|
2.38
|
1.69–3.34
|
<0.001
|
|
IPSSWM (I, II vs III)
|
1.37
|
0.95–1.97
|
0.097
|
1.08
|
0.81–1.45
|
0.588
|
1.85
|
1.35–2.50
|
<0.001
|
1.18
|
0.96–1.47
|
0.124
|
|
B symptom (+)
|
1.38
|
0.75–2.52
|
0.296
|
1.05
|
0.65–1.68
|
0.842
|
2.36
|
1.44–3.85
|
0.001
|
1.26
|
0.88–1.81
|
0.209
|
|
WBC <4 × 1012/L
|
1.39
|
0.69–2.82
|
0.360
|
1.41
|
0.80–2.47
|
0.234
|
1.09
|
0.51–1.65
|
0.776
|
1.19
|
0.79–1.80
|
0.395
|
|
Hb ≤11.5 g/L
|
1.26
|
0.68–2.34
|
0.460
|
0.97
|
0.59–1.57
|
0.886
|
1.53
|
0.46–2.45
|
0.076
|
0.99
|
0.70–1.40
|
0.958
|
|
PLT <100 × 109/L
|
1.63
|
0.88–3.06
|
0.123
|
1.37
|
0.81–2.32
|
0.243
|
1.78
|
1.06–2.99
|
0.030
|
1.59
|
1.08–2.36
|
0.019
|
|
IgM >7000 mg/L
|
0.24
|
0.03–1.74
|
0.158
|
0.40
|
0.14–1.10
|
0.075
|
0.35
|
0.08–1.43
|
0.143
|
0.51
|
0.26–1.00
|
0.052
|
|
β2-MG >3 mg/L
|
1.33
|
0.68–2.57
|
0.395
|
1.15
|
0.70–1.90
|
0.598
|
2.18
|
1.35–3.50
|
0.001
|
1.38
|
0.98–1.94
|
0.063
|
|
ALB <3.5 g/dL
|
2.12
|
1.12–4.00
|
0.020
|
1.21
|
0.69–2.13
|
0.501
|
2.64
|
1.61–4.35
|
<0.001
|
1.53
|
1.00–2.32
|
0.049
|
|
LDH >618 IU/L
|
1.18
|
0.41–3.37
|
0.757
|
1.49
|
0.75–2.93
|
0.250
|
1.78
|
0.95–3.31
|
0.070
|
2.02
|
1.29–3.15
|
0.002
|
|
Cytogenetic (abnormal)
|
1.08
|
0.57–2.03
|
0.823
|
1.71
|
1.03–2.83
|
0.039
|
1.37
|
0.83–2.23
|
0.208
|
1.77
|
1.23–2.55
|
0.002
|
|
BM involvement
|
0.99
|
0.97–1.00
|
0.093
|
0.99
|
0.98–1.00
|
0.172
|
1.00
|
0.99–1.01
|
0.666
|
1.00
|
0.99–1.00
|
0.417
|
-
CI confidence interval, HR hazard ratio, EM extramedullary, IPSSWM International Prognostic Scoring System for WM, WBC white blood cell account, Hb hemoglobin, PLT platelet, IgM immunoglobulin M, β2-MG beta-2 microglobulin level, ALB albumin, LDH lactate dehydrogenase, BM bone marrow
-
a
P value by Cox proportional hazards regression model; statistically significant values appear in italics
