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Table 2 Univariate analysis of overall survival (OS) and progression-free survival (PFS) for patients diagnosed with Waldenström macroglobulinemia (WM) with extramedullary involvement (EMWM)

From: Waldenström macroglobulinemia with extramedullary involvement at initial diagnosis portends a poorer prognosis

 

EMWM

WM

OS

PFS

OS

PFS

HR

95 % CI

P a

HR

95 % CI

P a

HR

95 % CI

P a

HR

95 % CI

P a

Age ≥65 years

1.90

1.02–3.54

0.044

1.04

0.63–1.73

0.876

2.09

1.32–3.32

0.002

1.09

0.77–1.56

0.598

Sex (male)

0.76

0.41–1.39

0.372

0.74

0.45–1.22

0.239

1.06

0.59–1.50

0.799

0.99

0.70–1.39

0.955

Race (white)

0.72

0.29–1.73

0.465

0.54

0.29–1.02

0.057

0.66

0.31–1.40

0.281

0.59

0.35–0.98

0.042

EM-positive

-

-

-

-

-

-

4.17

2.56–6.79

<0.001

2.38

1.69–3.34

<0.001

IPSSWM (I, II vs III)

1.37

0.95–1.97

0.097

1.08

0.81–1.45

0.588

1.85

1.35–2.50

<0.001

1.18

0.96–1.47

0.124

B symptom (+)

1.38

0.75–2.52

0.296

1.05

0.65–1.68

0.842

2.36

1.44–3.85

0.001

1.26

0.88–1.81

0.209

WBC <4 × 1012/L

1.39

0.69–2.82

0.360

1.41

0.80–2.47

0.234

1.09

0.51–1.65

0.776

1.19

0.79–1.80

0.395

Hb ≤11.5 g/L

1.26

0.68–2.34

0.460

0.97

0.59–1.57

0.886

1.53

0.46–2.45

0.076

0.99

0.70–1.40

0.958

PLT <100 × 109/L

1.63

0.88–3.06

0.123

1.37

0.81–2.32

0.243

1.78

1.06–2.99

0.030

1.59

1.08–2.36

0.019

IgM >7000 mg/L

0.24

0.03–1.74

0.158

0.40

0.14–1.10

0.075

0.35

0.08–1.43

0.143

0.51

0.26–1.00

0.052

β2-MG >3 mg/L

1.33

0.68–2.57

0.395

1.15

0.70–1.90

0.598

2.18

1.35–3.50

0.001

1.38

0.98–1.94

0.063

ALB <3.5 g/dL

2.12

1.12–4.00

0.020

1.21

0.69–2.13

0.501

2.64

1.61–4.35

<0.001

1.53

1.00–2.32

0.049

LDH >618 IU/L

1.18

0.41–3.37

0.757

1.49

0.75–2.93

0.250

1.78

0.95–3.31

0.070

2.02

1.29–3.15

0.002

Cytogenetic (abnormal)

1.08

0.57–2.03

0.823

1.71

1.03–2.83

0.039

1.37

0.83–2.23

0.208

1.77

1.23–2.55

0.002

BM involvement

0.99

0.97–1.00

0.093

0.99

0.98–1.00

0.172

1.00

0.99–1.01

0.666

1.00

0.99–1.00

0.417

  1. CI confidence interval, HR hazard ratio, EM extramedullary, IPSSWM International Prognostic Scoring System for WM, WBC white blood cell account, Hb hemoglobin, PLT platelet, IgM immunoglobulin M, β2-MG beta-2 microglobulin level, ALB albumin, LDH lactate dehydrogenase, BM bone marrow
  2. a P value by Cox proportional hazards regression model; statistically significant values appear in italics
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Journal of Hematology & Oncology

ISSN: 1756-8722

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