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Table 2 Univariate analysis of overall survival (OS) and progression-free survival (PFS) for patients diagnosed with Waldenström macroglobulinemia (WM) with extramedullary involvement (EMWM)

From: Waldenström macroglobulinemia with extramedullary involvement at initial diagnosis portends a poorer prognosis

  EMWM WM
OS PFS OS PFS
HR 95 % CI P a HR 95 % CI P a HR 95 % CI P a HR 95 % CI P a
Age ≥65 years 1.90 1.02–3.54 0.044 1.04 0.63–1.73 0.876 2.09 1.32–3.32 0.002 1.09 0.77–1.56 0.598
Sex (male) 0.76 0.41–1.39 0.372 0.74 0.45–1.22 0.239 1.06 0.59–1.50 0.799 0.99 0.70–1.39 0.955
Race (white) 0.72 0.29–1.73 0.465 0.54 0.29–1.02 0.057 0.66 0.31–1.40 0.281 0.59 0.35–0.98 0.042
EM-positive - - - - - - 4.17 2.56–6.79 <0.001 2.38 1.69–3.34 <0.001
IPSSWM (I, II vs III) 1.37 0.95–1.97 0.097 1.08 0.81–1.45 0.588 1.85 1.35–2.50 <0.001 1.18 0.96–1.47 0.124
B symptom (+) 1.38 0.75–2.52 0.296 1.05 0.65–1.68 0.842 2.36 1.44–3.85 0.001 1.26 0.88–1.81 0.209
WBC <4 × 1012/L 1.39 0.69–2.82 0.360 1.41 0.80–2.47 0.234 1.09 0.51–1.65 0.776 1.19 0.79–1.80 0.395
Hb ≤11.5 g/L 1.26 0.68–2.34 0.460 0.97 0.59–1.57 0.886 1.53 0.46–2.45 0.076 0.99 0.70–1.40 0.958
PLT <100 × 109/L 1.63 0.88–3.06 0.123 1.37 0.81–2.32 0.243 1.78 1.06–2.99 0.030 1.59 1.08–2.36 0.019
IgM >7000 mg/L 0.24 0.03–1.74 0.158 0.40 0.14–1.10 0.075 0.35 0.08–1.43 0.143 0.51 0.26–1.00 0.052
β2-MG >3 mg/L 1.33 0.68–2.57 0.395 1.15 0.70–1.90 0.598 2.18 1.35–3.50 0.001 1.38 0.98–1.94 0.063
ALB <3.5 g/dL 2.12 1.12–4.00 0.020 1.21 0.69–2.13 0.501 2.64 1.61–4.35 <0.001 1.53 1.00–2.32 0.049
LDH >618 IU/L 1.18 0.41–3.37 0.757 1.49 0.75–2.93 0.250 1.78 0.95–3.31 0.070 2.02 1.29–3.15 0.002
Cytogenetic (abnormal) 1.08 0.57–2.03 0.823 1.71 1.03–2.83 0.039 1.37 0.83–2.23 0.208 1.77 1.23–2.55 0.002
BM involvement 0.99 0.97–1.00 0.093 0.99 0.98–1.00 0.172 1.00 0.99–1.01 0.666 1.00 0.99–1.00 0.417
  1. CI confidence interval, HR hazard ratio, EM extramedullary, IPSSWM International Prognostic Scoring System for WM, WBC white blood cell account, Hb hemoglobin, PLT platelet, IgM immunoglobulin M, β2-MG beta-2 microglobulin level, ALB albumin, LDH lactate dehydrogenase, BM bone marrow
  2. a P value by Cox proportional hazards regression model; statistically significant values appear in italics