Patient number
|
345
|
173
|
172
| |
Median age (range), years
|
26 (2–58)
|
26 (4–58)
|
26 (2–58)
|
0.830
|
Median weight (range), kg
|
62 (13–113)
|
61 (18–113)
|
63 (13–110)
|
0.388
|
Male sex, n (%)
|
201 (58.3)
|
100 (57.8)
|
101 (58.7)
|
0.863
|
Diagnosis, n (%)
| | | |
0.142
|
AML
|
137 (39.7)
|
69 (39.9)
|
68 (39.5)
| |
ALL
|
116 (33.6)
|
49 (28.3)
|
67 (39.0)
| |
CML
|
19 (5.5)
|
10 (5.8)
|
9 (5.2)
| |
MDS
|
38 (11.0)
|
24 (13.9)
|
14 (8.1)
| |
Others
|
35 (10.1)
|
21 (12.1)
|
14 (8.1)
| |
Disease status, SR/HR (n (%))
|
265 (76.8)/80 (23.2)
|
135 (78.0)/38 (22.0)
|
135 (78.0)/38 (22.0)
|
0.589
|
Conditioning regimen
| | | | |
MA
|
345 (100 %)
|
173 (100 %)
|
172 (100 %)
| |
No of HLA-A, B, DR mismatched
| | | |
0.302
|
0
|
2 (0.6 %)
|
1 (0.6 %)
|
1 (0.6 %)
| |
1
|
18 (5.2 %)
|
13 (7.5 %)
|
5 (2.9 %)
| |
2
|
74 (21.4 %)
|
34 (19.7)
|
40 (23.3 %)
| |
3
|
249 (72.2 %)
|
124 (71.1 %)
|
125 (72.2 %)
| |
Donor-recipient sex match, n (%)
| | | |
0.609
|
Male-male
|
132 (38.3)
|
63 (36.4)
|
69 (40.1)
| |
Male-female
|
89 (25.8)
|
42 (24.3)
|
47 (27.3)
| |
Female-male
|
71 (20.6)
|
38 (22.0)
|
33 (19.2)
| |
Female-female
|
53 (15.4)
|
30 (17.3)
|
23 (13.4)
| |
Donor-recipient relationship, n (%)
| | | |
0.419
|
Father-child
|
134 (38.8)
|
64 (37.0)
|
70 (40.7)
| |
Mother-child
|
45 (13.0)
|
28 (16.2)
|
17 (9.9)
| |
Sibling-sibling
|
103 (29.9)
|
53 (30.6)
|
50 (29.1)
| |
Child-parent
|
53 (15.4)
|
25 (14.5)
|
28 (16.3)
| |
Other
|
10 (2.9)
|
3 (1.7)
|
7 (4.1)
| |
ABO matched, n (%)
| | | |
0.345
|
Matched
|
196 (56.8)
|
102 (59.2)
|
94 (54.7)
| |
Major mismatched
|
64 (18.6)
|
34 (19.7)
|
30 (17.4)
| |
Minor mismatched
|
18 (5.2)
|
10 (5.8)
|
8 (4.7)
| |
Bidirect mismatched
|
67 (19.4)
|
27 (15.6)
|
40 (23.3)
| |
Cell compositions in allografts
| | | | |
Infused nuclear cells 108/kg
|
8.34 (1.78–23.69)
|
8.32 (1.78–23.59)
|
8.40 (2.12–23.69)
|
0.321
|
Infused CD34+ cells 106/kg
|
2.59 (0.39–16.82)
|
2.71 (0.39–14.47)
|
2.49 (0.58–16.82)
|
0.840
|
Infused lymphocytes 108/kg
|
2.95 (0.16–9.49)
|
2.88 (0.16–9.49)
|
3.06 (0.68–7.34)
|
0.107
|
Infused CD3+ cells 108/kg
|
2.00 (0.10–5.93)
|
2.00 (0.10–5.93)
|
1.99 (0.20–5.36)
|
0.575
|
Infused CD4+ cells 108/kg
|
1.10 (0.10–3.94)
|
1.09 (0.10–3.33)
|
1.13 (0.19–3.94)
|
0.371
|
Infused CD8+ cells 108/kg
|
0.70 (0.05–2.47)
|
0.69 (0.05–2.47)
|
0.72 (0.14–2.43)
|
0.452
|
Infused CD14+ cells 108/kg
|
1.49 (0.05–4.90)
|
1.50 (0.33–4.90)
|
1.48 (0.05–6.13)
|
0.769
|