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Table 1 Patient and donor characteristics

From: Donor-specific anti-human leukocyte antigen antibodies were associated with primary graft failure after unmanipulated haploidentical blood and marrow transplantation: a prospective study with randomly assigned training and validation sets

  All patients Training group Validation group P value
Patient number 345 173 172  
Median age (range), years 26 (2–58) 26 (4–58) 26 (2–58) 0.830
Median weight (range), kg 62 (13–113) 61 (18–113) 63 (13–110) 0.388
Male sex, n (%) 201 (58.3) 100 (57.8) 101 (58.7) 0.863
Diagnosis, n (%)     0.142
 AML 137 (39.7) 69 (39.9) 68 (39.5)  
 ALL 116 (33.6) 49 (28.3) 67 (39.0)  
 CML 19 (5.5) 10 (5.8) 9 (5.2)  
 MDS 38 (11.0) 24 (13.9) 14 (8.1)  
 Others 35 (10.1) 21 (12.1) 14 (8.1)  
Disease status, SR/HR (n (%)) 265 (76.8)/80 (23.2) 135 (78.0)/38 (22.0) 135 (78.0)/38 (22.0) 0.589
Conditioning regimen     
 MA 345 (100 %) 173 (100 %) 172 (100 %)  
No of HLA-A, B, DR mismatched     0.302
 0 2 (0.6 %) 1 (0.6 %) 1 (0.6 %)  
 1 18 (5.2 %) 13 (7.5 %) 5 (2.9 %)  
 2 74 (21.4 %) 34 (19.7) 40 (23.3 %)  
 3 249 (72.2 %) 124 (71.1 %) 125 (72.2 %)  
Donor-recipient sex match, n (%)     0.609
 Male-male 132 (38.3) 63 (36.4) 69 (40.1)  
 Male-female 89 (25.8) 42 (24.3) 47 (27.3)  
 Female-male 71 (20.6) 38 (22.0) 33 (19.2)  
 Female-female 53 (15.4) 30 (17.3) 23 (13.4)  
Donor-recipient relationship, n (%)     0.419
 Father-child 134 (38.8) 64 (37.0) 70 (40.7)  
 Mother-child 45 (13.0) 28 (16.2) 17 (9.9)  
 Sibling-sibling 103 (29.9) 53 (30.6) 50 (29.1)  
 Child-parent 53 (15.4) 25 (14.5) 28 (16.3)  
 Other 10 (2.9) 3 (1.7) 7 (4.1)  
ABO matched, n (%)     0.345
 Matched 196 (56.8) 102 (59.2) 94 (54.7)  
 Major mismatched 64 (18.6) 34 (19.7) 30 (17.4)  
 Minor mismatched 18 (5.2) 10 (5.8) 8 (4.7)  
 Bidirect mismatched 67 (19.4) 27 (15.6) 40 (23.3)  
Cell compositions in allografts     
 Infused nuclear cells 108/kg 8.34 (1.78–23.69) 8.32 (1.78–23.59) 8.40 (2.12–23.69) 0.321
 Infused CD34+ cells 106/kg 2.59 (0.39–16.82) 2.71 (0.39–14.47) 2.49 (0.58–16.82) 0.840
 Infused lymphocytes 108/kg 2.95 (0.16–9.49) 2.88 (0.16–9.49) 3.06 (0.68–7.34) 0.107
 Infused CD3+ cells 108/kg 2.00 (0.10–5.93) 2.00 (0.10–5.93) 1.99 (0.20–5.36) 0.575
 Infused CD4+ cells 108/kg 1.10 (0.10–3.94) 1.09 (0.10–3.33) 1.13 (0.19–3.94) 0.371
 Infused CD8+ cells 108/kg 0.70 (0.05–2.47) 0.69 (0.05–2.47) 0.72 (0.14–2.43) 0.452
 Infused CD14+ cells 108/kg 1.49 (0.05–4.90) 1.50 (0.33–4.90) 1.48 (0.05–6.13) 0.769
  1. Abbreviations: AML acute myeloid leukemia, ALL acute lymphoblastic leukemia, CML chronic myeloid leukemia, MDS myelodysplastic syndrome, HLA human leukocyte antigen, BM bone marrow