Table 1 Patient and donor characteristics

Patient number

345

173

172

Median age (range), years

26 (2–58)

26 (4–58)

26 (2–58)

0.830

Median weight (range), kg

62 (13–113)

61 (18–113)

63 (13–110)

0.388

Male sex, n (%)

201 (58.3)

100 (57.8)

101 (58.7)

0.863

Diagnosis, n (%)

0.142

 AML

137 (39.7)

69 (39.9)

68 (39.5)

 ALL

116 (33.6)

49 (28.3)

67 (39.0)

 CML

19 (5.5)

10 (5.8)

9 (5.2)

 MDS

38 (11.0)

24 (13.9)

14 (8.1)

 Others

35 (10.1)

21 (12.1)

14 (8.1)

Disease status, SR/HR (n (%))

265 (76.8)/80 (23.2)

135 (78.0)/38 (22.0)

135 (78.0)/38 (22.0)

0.589

Conditioning regimen

 MA

345 (100 %)

173 (100 %)

172 (100 %)

No of HLA-A, B, DR mismatched

0.302

 0

2 (0.6 %)

1 (0.6 %)

1 (0.6 %)

 1

18 (5.2 %)

13 (7.5 %)

5 (2.9 %)

 2

74 (21.4 %)

34 (19.7)

40 (23.3 %)

 3

249 (72.2 %)

124 (71.1 %)

125 (72.2 %)

Donor-recipient sex match, n (%)

0.609

 Male-male

132 (38.3)

63 (36.4)

69 (40.1)

 Male-female

89 (25.8)

42 (24.3)

47 (27.3)

 Female-male

71 (20.6)

38 (22.0)

33 (19.2)

 Female-female

53 (15.4)

30 (17.3)

23 (13.4)

Donor-recipient relationship, n (%)

0.419

 Father-child

134 (38.8)

64 (37.0)

70 (40.7)

 Mother-child

45 (13.0)

28 (16.2)

17 (9.9)

 Sibling-sibling

103 (29.9)

53 (30.6)

50 (29.1)

 Child-parent

53 (15.4)

25 (14.5)

28 (16.3)

 Other

10 (2.9)

3 (1.7)

7 (4.1)

ABO matched, n (%)

0.345

 Matched

196 (56.8)

102 (59.2)

94 (54.7)

 Major mismatched

64 (18.6)

34 (19.7)

30 (17.4)

 Minor mismatched

18 (5.2)

10 (5.8)

8 (4.7)

 Bidirect mismatched

67 (19.4)

27 (15.6)

40 (23.3)

Cell compositions in allografts

 Infused nuclear cells 10⁸/kg

8.34 (1.78–23.69)

8.32 (1.78–23.59)

8.40 (2.12–23.69)

0.321

 Infused CD34⁺ cells 10⁶/kg

2.59 (0.39–16.82)

2.71 (0.39–14.47)

2.49 (0.58–16.82)

0.840

 Infused lymphocytes 10⁸/kg

2.95 (0.16–9.49)

2.88 (0.16–9.49)

3.06 (0.68–7.34)

0.107

 Infused CD3⁺ cells 10⁸/kg

2.00 (0.10–5.93)

2.00 (0.10–5.93)

1.99 (0.20–5.36)

0.575

 Infused CD4⁺ cells 10⁸/kg

1.10 (0.10–3.94)

1.09 (0.10–3.33)

1.13 (0.19–3.94)

0.371

 Infused CD8⁺ cells 10⁸/kg

0.70 (0.05–2.47)

0.69 (0.05–2.47)

0.72 (0.14–2.43)

0.452

 Infused CD14⁺ cells 10⁸/kg

1.49 (0.05–4.90)

1.50 (0.33–4.90)

1.48 (0.05–6.13)

0.769