Favorable outcome of haploidentical hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia: a multicenter study in Southwest China

Table 4 Results of univariate analysis of RE, LFS and OS

	RE		LFS		OS
Variable	HR(95 % CI)	P	HR(95 % CI)	P	HR(95 % CI)	P
Age
<40 years	1(Reference)		1(Reference)		1(Reference)
≥40 years	0.752(0.279–2.026)	0.573	0.932(0.454–1.913)	0.849	0.954(0.427–2.314)	0.910
HLA disparity
Identical HSCT	1(Reference)		1(Reference)		1(Reference)
Haploidentical HSCT	0.399(0.173–0.924)	0.032	0.609(0.325–1.143)	0.123	0.889(0.438–1.803)	0.744
Duration from diagnosis to SCT
<180 days	1(Reference)		1(Reference)		1(Reference)
≥180 days	1.775(0.783–4.025)	0.169	1.389(0.740–2.609)	0.306	0.915(0.444–1.886)	0.810
Disease status before transplantation
CR1	1(Reference)		1(Reference)		1(Reference)
>CR1	3.289(1.429–7.569)	0.005	2.279(1.179–4.408)	0.014	1.711(0.804–3.642)	0.164
WBC at diagnosis
<30 × 10⁹/L	1(Reference)		1(Reference)		1(Reference)
≥30 × 10⁹/L	2.272(1–5.165)	0.05	1.842(0.976–3.478)	0.06	1.590(0.778–3.249)	0.204
Acute GVHD
Yes	1(Reference)		1(Reference)		1(Reference)
No	0.562(0.235–1.366)	0.204	0.814(0.427–1.552)	0.532	1.208(0.595–2.451)	0.601
Chronic GVHD
Yes	1(Reference)		1(Reference)		1(Reference)
No	0.5(0.253–0.988)	0.046	0.570(0.241–1.346)	0.2	0.584(0.275–1.242)	0.162
CMV
Positive	1(Reference)		1(Reference)		1(Reference)
Negative	0.511(0.173–1.506)	0.223	1.087(0.55–2.148)	0.81	1.508(0.721–3.155)	1.508

ISSN: 1756-8722