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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment

Fig. 5

Elevated CD244 and PD-1 expression on differentiated effector T cells. Peripheral blood CD8+ T cells were classified into naïve (Tnaive; CD45RA+/CCR7+, (a, c)) and effector memory (Tem; CD45RA/CCR7, (b, d)) T cells, and expression of CD244 (a, b) and PD-1 (c, d) was measured for AML patients at diagnosis (AML_diag; n = 14 and n = 10), patients with an AML relapse after intensive chemotherapy (AML_rel; n = 9 and n = 9), and patients with an AML relapse after allogeneic SCT (AML_rel_allo; n = 6 and n = 4) in comparison to healthy controls (HC, n = 9 and n = 5). Percentages of positive cells were depicted. Statistical differences were calculated to HC. *p ≤ 0.05

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