Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 | Average | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
CD45+ | CD19+ | CD45+ | CD19+ | CD45+ | CD19+ | CD45+ | CD19+ | CD45+ | CD19+ | CD45+ | CD19+ | |
PBS | 87.8 ± 6.8 | 87.6 ± 9.9 | 83.5 ± 7.3 | 83.9 ± 8.9 | 79.2 ± 9.2 | 79.6 ± 6.7 | 85.1 ± 6.1 | 85.7 ± 8.3 | 88.3 ± 8.1 | 88.5 ± 10.4 | 84.8 ± 5.6 | 85.1 ± 5.5 |
T | 82.1 ± 5.9 | 82.8 ± 6.1 | 80.1 ± 9.4 | 80.6 ± 5.4 | 78.2 ± 7.1 | 78.9 ± 7.8 | 81.2 ± 5.9 | 81.0 ± 7.9 | 80.9 ± 10.9 | 81.2 ± 7.8 | 80.5 ± 2.3 | 80.9 ± 2.0 |
T + diabody | 60.0 ± 7.2 | 59.8 ± 5.7 | 60.1 ± 1.6 | 59.5 ± 5.6 | 58.8 ± 6.1 | 58.5 ± 6.5 | 62.5 ± 2.6 | 61.9 ± 6.4 | 62.6 ± 5.7 | 63.0 ± 3.4 | 60.8 ± 2.0* | 60.5 ± 2.0* |
T + ds-diabody | 49.5 ± 5.5 | 48.7 ± 6.2 | 47.6 ± 3.2 | 48.1 ± 7.1 | 46.3 ± 4.6 | 46.0 ± 5.7 | 49.1 ± 4.3 | 49.7 ± 5.1 | 50.4 ± 7.2 | 50.7 ± 2.7 | 48.6 ± 2.3* | 48.6 ± 2.6* |
T + Ara-C | 77.0 ± 8.1 | 77.8 ± 7.4 | 67.3 ± 3.3 | 68.0 ± 4.6 | 70.1 ± 5.6 | 69.9 ± 6.9 | 72.0 ± 6.8 | 70.8 ± 3.8 | 75.1 ± 5.3 | 75.5 ± 5.5 | 72.3 ± 5.0 | 72.4 ± 2.5 |
T + Ara-C + diabody | 21.5 ± 3.2 | 20.8 ± 2.8 | 15.8 ± 3.1 | 15.0 ± 3.3 | 14.3 ± 2.7 | 13.9 ± 3.7 | 19.7 ± 2.1 | 19.1 ± 0.9 | 17.8 ± 1.1 | 17.9 ± 2.7 | 17.8 ± 3.5** | 17.3 ± 3.4** |
T + Ara-C + ds-diabody | 1.3 ± 0.5 | 1.2 ± 0.4 | 0.8 ± 0.2 | 0.7 ± 0.1 | 0.7 ± 0.2 | 0.5 ± 0.1 | 2.5 ± 0.3 | 2.4 ± 0.4 | 2.0 ± 1.2 | 2.1 ± 0.5 | 1.5 ± 0.8** | 1.4 ± 0.9** |