Fig. 5
From: Roles of palmitoylation and the KIKK membrane-targeting motif in leukemogenesis by oncogenic KRAS4A
KIKK of KRAS4A functions as a second plasma membrane association motif. NIH3T3 cells expressing GFP-fused KRAS4AG12D a, KRAS4AG12D/C180S b, KRAS4AG12D/QIQQ c, or KRAS4AG12D/C180S/QIQQ d were visualized on a Leica TCS 7300 Spectral Confocal Microscope (original magnification, ×630). e The comparison of plasma membrane localization ratios of each KRAS4A mutant. Ten representative cells of each group were photographed and analyzed by LAS AF Lite Software. PM plasma membrane; Student t test was used for the statistical analysis. ****P < 0.0001