Fig. 1

a Schematic representation of the HR-MDS mouse model. The characteristics of this model have previously been published ^[24-26;29]. b Decrease of the HR-MDS mice survival compared to its single transgenic mice founders, _MRP8NRASD12 and _tethBCL-2 transgenic mice; c Increased level of Lin-Sca1+-cKit+ (LSK) cells in the BM; d Increased apoptosis in the liver and spleen seen by whole body SPECT using ⁹⁹Tc-Annexin (liver and spleen region located above the kidneys); e The disease can be transplanted in normal FVB/N irradiated syngeneic mice with either the Sca1+ cells of the spleen or BM of the HR-MDS mice resulting in 15 % blast infiltration in the BM blasts as in HR-MDS mice^[24-26;29]