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Table 4 Top regulated pathways in the list of upregulated genes in AML post MDS mice

From: GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

Functional pathway KEGG database n Up P Value Upregulated genesa
Cell metabolism
Oxidative phosphorylation
18 1.0E-03 NDUFB5, NDUFB6, NDUFB8, ATP5B, COX4I1, NDUFC1, COX5A, LHPP, NDUFA10, ATP5G3, PPA2, NDUFB2, ATP6V0C, ATP6V1A, UQCR11, NDUFV1, SDHC, COX6B2
NDUF family: NADH dehydrogenase (ubiquinone) Fe-S family
SDHC: succinate dehydrogenase complex, subunit C
LHPP: phospholysine phosphohistidine inorganic pyrophosphate phosphatase
Nucleotide metabolism Pyrimidine metabolism 14 2.9E-03 POLR2G, NUDT2, DTYMK, POLE, AK3, POLA1, POLR2C, NME4, TYMP, POLE3, NME1, POLD1, ENTPD1, DUT
NUDT2: nucleoside diphosphate, AK3: adenylate kinase
TYMP: thymidine phosphorylase, NME: nucleoside diphosphate kinase
POLE, POLR2C, POLE3, PLD1: polymerases, DUT: deoxyuridine triphosphate
Immune system
Toll-like receptor signaling
14 3.8E-03 MAP2K3, MAP2K4, TLR4, FADD, CXCL11, TLR7, CCL4, TLR8, CD80, IFNA7, MAPK13, IFNA5, TICAM2, PIK3R2
MAP2K3, MAP2K4: MEK proteins, TICAM2: TIR domain-containing adapter molecule 2
PIK3R2: Phosphatidylinositol 3-kinase regulatory subunit beta
Cellular processes
Cell cycle
16 5.8E-03 CDC6, E2F3, CCNH, SKP2, YWHAB, ESPL1, CDC20, CHEK1, CHEK2, CDC25C, MCM4, 2CDK2, CCNE2, CDC45, MAD2L1, CDKN2C
CCNH: cyclin H; SKP2: S-phase kinase-associated protein 2; YWHAB: 14-3-3 protein beta/alpha
ESPL1:separin, CCNE2: cyclin E2, MAD2L1: MAD2 mitotic arrest deficient-like 1
CDKN2: cyclin-dependent kinase inhibitor 2A (p16)
Signaling molecules Cytokine-cytokine receptor 25 5.9E-03 IL1R1, ACVRL1, PDGFB, IL13, CXCL11, CCL4, TNFRSF4, IL10, IL12RB2, CCL22, IFNA7, IFNA5, TNFRSF18, IFNGR1, EPO, IL4, IL23R, IL21, CCL17, TNFRSF9, INHBA, CCR8, TNFSF11, CXCL13, CCR2
IL1R1, IL12RB, I L23R,IL21: interleukines/interleukine receptor
CCL4, CCL22, CCL17, CXCL11, CXCL13 CCR2, CCR8: chemokine
TNFRSF4, TNFRSF18, TNFRSF9, TNFSF11. Tumor necrosis receptor
IFNA7, IFNA5, INFGR1, INHBA: interferon signaling
EPO: erythropoietin
Signal transduction
JAK-STAT signaling pathway
15 5.0E-02 IL4, IL23R, SOCS2, IL13, IL21, IL10, IL12RB2, SPRY1, IFNA7, IFNA5, SPRED2, IFNGR1, IL13RA2, EPO, PIK3R2
IL4, IL23R, IL13, IL21, IL10, IL12RB2, IL13RA2: interleukines/interleukine receptor
IFNA7, IFNA5, IFNGR1: interferon signaling
EPO: erythropoietin
PIK3R2: phosphoinositide-3-kinase, regulatory subunit 2
Genetic information processing. Replication and repair 5 6.4E-02 BLM, RAD51L1, POLD1, RAD54B, RAD51
BLM: bloom syndrome protein, POLD1: polymerase delta
RAD51L1, RAD54B, RAD51: recombinases family
Genetic information processing 11 6.8E-02 HIST1H2AC, C4A, H2AFV, CD80, HIST2H2BE, HIST2H2AC, HIST1H2BH, HIST1H2AI, SNRPB, H2AFY, FCGR1, IL10
HIST1H2AC,H2AFV,HIST2H2BE,HIST2H2AC,HIST1H2BH, HIST1H2AI, H2AFY: histone proteins
C4A: complement factor 4; CD80, costimulatory factor, SNRPB: small nuclear ribonucleoprotein-associated proteins B, FCGR1: IgG Fc receptor
  1. aGene card nomenclature