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Table 5 Top regulated pathways in the list of downregulated genes in AML post MDS mice

From: GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

Functional pathway KEGG database n Down P value Downregulated genesa
Cellular processes Inhibition of Apoptosis 5 1.2E-2 NAIP6, NAIP5, NLRC4, MAPK9, TNFAIP3
NAIP6; NAIP5: NLR family, apoptosis inhibitory protein 6; NLRC4: NLR family CARD domain-containing protein 4; MAPK9: mitogen activated kinase 9; TNFAIP3: tumor necrosis factor, alpha-induced protein 3
Environmental adaptation Circadian rhythm 3 1.4E-2 NR1D1, PER1, CLOCK
NR1D1: nuclear receptor subfamily 1, group D, member 1
PER1: period circadian clock 1
CLOCK: circadian locomotor output cycles kaput
Signal transduction Phosphatidylinositol signaling system 5 2.2E-2 PIK3C2A, PIK3C2B, PIP4K2A, PTEN, ITPR1
PIK3C2A: phosphatidylinositol-4-phosphate 3-kinase
PIP4K2A: phosphatidylinositol-5-phosphate 4-kinase, type II,
PTEN: phosphatase and tensin homolog
ITPR1: Inositol 1,4,5-trisphosphate receptor type 1
Human diseases
Type II diabetes mellitus
4 3.2E-2 IRS2, MAPK9, CACNA1E, SOCS4
IRS2: insulin receptor substrate 2; MAPK9: mitogen activated kinase 9
CACNA1E: calcium channel, voltage-dependent, R type, alpha 1E subunit
SOCS4: suppressor of cytokine signaling 4
Human diseases
Primary immunodeficiency
3 9.3E-2 CD19, RFX5, CD40
CD19: antigen receptor of B lymphocytes; RFX5: regulatory factor X ; CD40: TNF receptor superfamily member 5