Table 6 Genes implicated in WNT signaling differentially dysregulated in the AML post MDS transgenic mice compared to control FVB/N mice
Gene symbol | Gene name | Regulation | Fold change | P value |
|---|---|---|---|---|
Mesdc2 | Mesoderm development candidate 2 | Up | 1.98 | 1.92E-02 |
Csnk2b | Casein kinase 2, beta polypeptide | Up | 1.88 | 1.76E-02 |
Fzd7 | Frizzled homolog 7 | Up | 1.75 | 2.74E-03 |
Ctnnb1 | Catenin (cadherin associated protein), beta 1 | Up | 1.74 | 4.24E-04 |
Bambi | BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis) | Up | 1.73 | 1.56E-02 |
Dab2 | Disabled homolog 2 | Up | 6.67 | 2.12E-02 |
Cd44 | CD44 antigen | Up | 1.68 | 5.96E-03 |
Wdr61 | WD repeat domain 61 | Up | 1.64 | 7.57E-04 |
Sdc1 | Syndecan 1 | Up | 3.11 | 5.94E-03 |
Hhex | Hematopoietically expressed homeobox | Down | 1.98 | 2.46E-02 |
Macf1 | Microtubule-actin crosslinking factor 1 | Down | 1.94 | 8.80E-03 |
Mark2 | MAP/microtubule affinity-regulating kinase 2 | Down | 1.94 | 2.41E-02 |
Tnik | TRAF2 and NCK interacting kinase | Down | 1.91 | 3.10E-03 |
Tle1 | Transducin-like enhancer of split 1, homolog of Drosophila E(spl) | Down | 1.88 | 1.51E-02 |
Dvl2 | Dishevelled 2, dsh homolog (Drosophila) | Down | 1.67 | 7.34E-03 |
Csnk1a1 | Casein kinase 1, alpha 1 | Down | 1.65 | 1.27E-02 |
Rock1 | Rho-associated coiled-coil containing protein kinase 1 | Down | 1.61 | 7.04E-03 |
Map3k7 | Mitogen-activated protein kinase kinase kinase 7 | Down | 1.58 | 9.96E-04 |
Smad4 | MAD homolog 4 | Down | 1.54 | 6.36E-03 |
Dapk3 | Death-associated protein kinase 3 | Down | 1.52 | 1.06E-02 |
Tbl1xr1 | Transducin (beta)-like 1X-linked receptor 1 | Down | 1.52 | 8.39E-04 |
Ppp3ca | Protein phosphatase 3, catalytic subunit, alpha isoform | Down | 1.50 | 9.70E-03 |
Ppap2b | Phosphatidic acid phosphatase type 2B | Down | 2.10 | 2.74E-02 |