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Table 6 Genes implicated in WNT signaling differentially dysregulated in the AML post MDS transgenic mice compared to control FVB/N mice

From: GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways

Gene symbol Gene name Regulation Fold change P value
Mesdc2 Mesoderm development candidate 2 Up 1.98 1.92E-02
Csnk2b Casein kinase 2, beta polypeptide Up 1.88 1.76E-02
Fzd7 Frizzled homolog 7 Up 1.75 2.74E-03
Ctnnb1 Catenin (cadherin associated protein), beta 1 Up 1.74 4.24E-04
Bambi BMP and activin membrane-bound inhibitor, homolog (Xenopus laevis) Up 1.73 1.56E-02
Dab2 Disabled homolog 2 Up 6.67 2.12E-02
Cd44 CD44 antigen Up 1.68 5.96E-03
Wdr61 WD repeat domain 61 Up 1.64 7.57E-04
Sdc1 Syndecan 1 Up 3.11 5.94E-03
Hhex Hematopoietically expressed homeobox Down 1.98 2.46E-02
Macf1 Microtubule-actin crosslinking factor 1 Down 1.94 8.80E-03
Mark2 MAP/microtubule affinity-regulating kinase 2 Down 1.94 2.41E-02
Tnik TRAF2 and NCK interacting kinase Down 1.91 3.10E-03
Tle1 Transducin-like enhancer of split 1, homolog of Drosophila E(spl) Down 1.88 1.51E-02
Dvl2 Dishevelled 2, dsh homolog (Drosophila) Down 1.67 7.34E-03
Csnk1a1 Casein kinase 1, alpha 1 Down 1.65 1.27E-02
Rock1 Rho-associated coiled-coil containing protein kinase 1 Down 1.61 7.04E-03
Map3k7 Mitogen-activated protein kinase kinase kinase 7 Down 1.58 9.96E-04
Smad4 MAD homolog 4 Down 1.54 6.36E-03
Dapk3 Death-associated protein kinase 3 Down 1.52 1.06E-02
Tbl1xr1 Transducin (beta)-like 1X-linked receptor 1 Down 1.52 8.39E-04
Ppp3ca Protein phosphatase 3, catalytic subunit, alpha isoform Down 1.50 9.70E-03
Ppap2b Phosphatidic acid phosphatase type 2B Down 2.10 2.74E-02