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Table 2 The signaling pathway of CCL25/CCR9 in cancer chemoresistance and metastasis

From: CCR9 in cancer: oncogenic role and therapeutic targeting

  Pathway Reference
Tumor chemoresistance PI3K/AKT Lung cancer [12], prostate cancer [14], breast cancer [15], ovarian cancer [16]
P-gp/ERM/F-actin T-ALL [17, 18]
STAT Breast cancer [19]
β-catenin/cyclin Pancreatic cancer [20]
Tumor metastasis MMPs Ovarian cancer [21], prostate cancer [22], non-small cell lung cancer [23], endometriosis [24]
RhoA-ROCK-MLC/ezrin T-ALL [26, 27]
Paracrine of chemokines Pancreatic cancer [28]
Lymphocyte homing Melanoma [29, 31], lymphoblastic leukemia [32]
PTEN signaling T-ALL [33]